Kudus is set to begin his medical with Spurs on today ahead of signing a six-year contract.
If it goes through, this will be the first transfer between the two rivals since Scott Parker joined Spurs from West Ham in 2011.
The fee for the 24-year-old forward is understood to be around £55m.
Spurs remain interested in Brentford’s Yoane Wissa after the expected arrival of Kudus.
